ASSESSMENT OF ERYTHROPOIETIN, COMPLETE BLOOD COUNT AND COAGULATORY EFFECT OF CADABA FARINOSA IN EXPERIMENTAL GASTRIC ULCER

Abstract

Gastric ulcers are a common gastrointestinal disorder resulting from disruption of the gastric mucosal barrier, often due to Helicobacter pylori infection, NSAID use, and other aggressive factors. This study evaluated the effect of Cadaba farinosa leaf extract on PTTK and full blood count in aspirin-induced gastric ulcer in Adult Wistar rats. Thirty adult Wistar rats were randomly divided into six groups: negative control, positive control (ulcer only), three treatment groups receiving graded doses of C. farinosa extract (250, 500, and 1000 mg/kg), and a standard drug group (omeprazole, 20 mg/kg). Gastric ulcers were induced using aspirin. After 14 days of treatment, blood samples were analyzed for full blood count using hematology auto analyzer, and coagulation status was assessed using Partial Thromboplastin Time with Kaolin (PTTK). The positive control group showed reduced RBC (6.8 + 0.3 x 106/uL), Hb (13.5 + g/dl), and platelets (290 + 15 x 103/uL), alongside prolonged PTTK (35 + 0.2 Seconds), indicating anemia, thrombocytopenia, and impaired coagulation. Treatment with C. farinosa significantly improved hematological indices and normalized clotting times in a dose-dependent manner. The medium dose (500 mg/kg) produced the greatest effect, with increases in Hb (+1.0 g/dL), platelets (+30 ×10³/µL), and a reduction in clotting time (–5.0 sec) compared to untreated ulcer-induced adult wistar rats. The high dose was less effective, suggesting a biphasic response, while omeprazole showed similar normalization effects.
Cadaba farinosa demonstrated hematoprotective and coagulatory benefits in ulcer-induced adult wistar rats, supporting its ethnomedicinal use in managing gastrointestinal and bleeding disorders. The extract improved anemia-related parameters, normalized platelet counts, and restored clotting balance, with the medium dose showing optimal therapeutic effect.