HISTOLOGICAL AND BIOCHEMICAL EFFECT OF AZADIRACHTA INDICA ONDIABETES-INDUCED TESTICULAR DAMAGE

Abstract

Introduction: Infertility is among the major health problems of people living with diabetes. The suggestion that herbal drugs has promising effects on the male infertility is contentious.
This study aimed to determine the effect of Azadirachta indica on diabetes-induced testicular damage.

Materials and Methods: Twenty-four Wistar rats were allotted into six groups (n=4). Group  I was normal control. Group II was induced with diabetes but not treated. Groups IV-VI were induced with diabetes and treated with 200, 300, and4300 mg/kg extracts while Group III was treated with Metformin once daily for 14 days. Animals were euthanized, and blood samples were collected for Glucose and Testosterone assays while testes were excised and processed by the paraffin wax method.
Result: Oral administration of Azadirachta indica extract significantly (P<0.05) reduced blood glucose, and increased testosterone levels in diabetic animals in a dose-dependent manner. Extract also improved the histology of the testes.

Conclusion: Azadirachta indica phytochemicals reduced blood glucose level and improved the histology of the testis. Further study is recommended to identify the phytochemicals and mechanism of action.